How the evidence connects

Three orders of evidence

Explanatory scale, the origin of a proposition and the role of a study are different questions. Keeping them separate lets a molecular intervention and a population dataset contribute to the same explanation without pretending that they measure the same link.

L0 is g = η + A⊗A. L1 follows by A = Ab + a: δg = Ab⊗a + a⊗Ab + a⊗a. At L2, BERM conditionally derives a formal response operator under minimal matter–metric coupling and causal response theory; z = ∫K(S):δg is a receptor-specific temporal representation. Gauge, scale, tissue kernels, sign, lag and endpoint calibration remain open. The studies below establish or constrain L3 biological realizations and L4 downstream relationships; their composition continues through this explicit bridge. Lindgren 2025 ↗iElectromagnetism as a purely geometric theoryJournal of Physics: Conference Series · 2025 · journalMétadonnées vérifiées; Kubo 1957 ↗iStatistical-Mechanical Theory of Irreversible Processes. I. General Theory and Simple Applications to Magnetic and Conduction ProblemsJournal of the Physical Society of Japan · 1957 · journalMétadonnées vérifiées.

CRY, hormone receptors and clocks close a regulatory loop

1. Upstream quantity

   Field response and CRY state

2. Shared interface

   Receptor response / cAMP / clock phase

3. Downstream output

   A changed response to the next signal

This connection joins the physical-reception literature to the machinery that determines hormone effectiveness. It also returns endocrine state to the receiver: biological phase and steroid signaling can change subsequent responsiveness.

Hormone action depends on temporal structure

1. Upstream quantity

   Dose, pulses and clock phase

2. Shared interface

   Time-dependent tissue receptivity

3. Downstream output

   Gene, emotional and cognitive responses

The CRY–receptor circuit becomes more explanatory when the signal retains its timing. Receptor responsiveness can vary while circulating abundance remains similar, and a different pulse pattern can produce a different accumulated response.

The reproductive axis reaches both function and motivation

1. Upstream quantity

   Hormonal and neural regulation

2. Shared interface

   Sexual processing and responsiveness

3. Downstream output

   Initiation, partner response and reproductive opportunity

A reproductive model needs the formation of an attempt as well as success conditional on it. The biological system contributes to both. This makes desire and initiative part of the explanation rather than fixed external inputs.

Biological state changes what effort is worth

1. Upstream quantity

   Dopamine, sleep or inflammatory state

2. Shared interface

   Reward and effort weights

3. Downstream output

   Willingness to choose an available action

Several interventions converge on the distinction between being able to perform a task and wanting to select it. Their value for BERM lies in the decision variables they identify, including different responses to cognitive and physical effort.

The reported reason is an observable in the chain

1. Upstream quantity

   State, valuation and chosen outcome

2. Shared interface

   Interpretation and deliberation

3. Downstream output

   Expressed reasons and later commitments

A reason can describe a decision, help form it, and later guide another decision. Its place in the chain depends on timing. BERM treats the experienced value and the explanation of that value as outputs of the same biological and cognitive process.

Social values and learning carry state into later action

1. Upstream quantity

   Neuromodulatory, nutritional and sleep state

2. Shared interface

   Harm weights and feedback updating

3. Downstream output

   Social choices and accumulated action history

Socially consequential decisions remain decisions made by biological organisms. The bridge to durable patterns is the combination of current valuation with learning: today’s state affects both today’s action and what is carried into the next encounter.

One organism’s output becomes another’s environment

1. Upstream quantity

   Initiatives, responses and repeated actions

2. Shared interface

   Dyadic interaction and network position

3. Downstream output

   Collective outcomes and institutional renewal

The transition to society is a composition of encounters. Pair success depends on both participants; propagation depends on who interacts with whom and how actions alter future participation. Stored consequences give institutions and ecosystems their longer timescales.

Parsimony in the joint pattern

BERM derives physiological and behavioral outputs from a shared time-dependent biological state; the field-to-state coupling is the separately specified upstream step of the chain.

Parsimony becomes substantive when the same measured states explain several outcomes together. Near a specified baseline, a local approximation is ΔY = JΔS + ε. If k shared state variables generate the shared component, its covariance JΣS Jᵀ has rank at most k. This is a conditional mathematical constraint, not a covariance pattern already demonstrated for BERM.

This makes studies measuring hormones, desire, fatigue, choice and perceived change in the same people especially valuable. Different publications from the same cohort supply connected outputs. Independent interventions reaching the same interface provide another kind of convergence. Publication count alone measures neither kind.

Data that join the levels

These existing resources make the proposed interfaces concrete. Availability describes the actual shared material; access-controlled individual data are distinguished from public derivatives. The synthesis identifies analyses to do rather than reporting a reanalysis already performed.